Abstract
This article reviews the history of clinical trials in surgery using breast cancer surgery and rectal cancer surgery as examples. Trials in breast cancer have transformed the surgical management of this disease. Rectal cancer surgery has also changed greatly, but much of this evolution occurred outside the setting of clinical trials. This article highlights the strengths and limitations of surgical trials and suggests that future studies should include pretrial credentialing as a requirement for surgeon participation. More work needs to be done to bridge the gap from trial results to implementation of new techniques in clinical practice.
Original language | English (US) |
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Pages (from-to) | 449-466 |
Number of pages | 18 |
Journal | Surgical Oncology Clinics of North America |
Volume | 21 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2012 |
Keywords
- Oncology
- Randomized controlled trial
- Rectal cancer
- Surgery
ASJC Scopus subject areas
- Surgery
- Oncology