Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses

Dirk Rades, Stefan Huttenlocher, Volker Rudat, Dagmar Hornung, Oliver Blanck, Pham Cam Phuong, Mai Trong Khoa, Steven E. Schild, Dorothea Fischer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Patients and Methods: Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.

Aim: To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.

Results: Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60%, respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40%, respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).

Conclusion: Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalAnticancer research
Issue number1
StatePublished - Jan 1 2015


  • Brain metastasis
  • Breast cancer
  • Distant brain control
  • Local control
  • Overall survival
  • Radiation dose
  • Radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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