Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Ahmed M. Osman, Ying Sun, Terry C. Burns, Liqun He, Nigel Kee, Nuria Oliva-Vilarnau, Androniki Alevyzaki, Kai Zhou, Lauri Louhivuori, Per Uhlén, Eva Hedlund, Christer Betsholtz, Volker M. Lauschke, Julianna Kele, Klas Blomgren

Research output: Contribution to journalArticlepeer-review

Abstract

Osman et al. show that microglia undergo transient changes after radiation, displaying a series of temporally distinct molecular signatures with a trajectory toward baseline within one week and suggesting a narrow time window for any therapeutic interventions specifically targeting early microglial activation after irradiation.

Original languageEnglish (US)
Article number107699
JournalCell reports
Volume31
Issue number9
DOIs
StatePublished - Jun 2 2020

Keywords

  • M1 and M2
  • RNA sequencing
  • neuroinflammation
  • radiotherapy
  • transcriptome

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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