Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Ahmed M. Osman; Ying Sun; Terry C. Burns; Liqun He; Nigel Kee; Nuria Oliva-Vilarnau; Androniki Alevyzaki; Kai Zhou; Lauri Louhivuori; Per Uhlén; Eva Hedlund; Christer Betsholtz; Volker M. Lauschke; Julianna Kele; Klas Blomgren

doi:10.1016/j.celrep.2020.107699

Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Ahmed M. Osman, Ying Sun, Terry C. Burns, Liqun He, Nigel Kee, Nuria Oliva-Vilarnau, Androniki Alevyzaki, Kai Zhou, Lauri Louhivuori, Per Uhlén, Eva Hedlund, Christer Betsholtz, Volker M. Lauschke, Julianna Kele, Klas Blomgren

Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

Osman et al. show that microglia undergo transient changes after radiation, displaying a series of temporally distinct molecular signatures with a trajectory toward baseline within one week and suggesting a narrow time window for any therapeutic interventions specifically targeting early microglial activation after irradiation.

Original language	English (US)
Article number	107699
Journal	Cell reports
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.107699
State	Published - Jun 2 2020

Keywords

M1 and M2
RNA sequencing
neuroinflammation
radiotherapy
transcriptome

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.107699

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Osman, A. M., Sun, Y., Burns, T. C., He, L., Kee, N., Oliva-Vilarnau, N., Alevyzaki, A., Zhou, K., Louhivuori, L., Uhlén, P., Hedlund, E., Betsholtz, C., Lauschke, V. M., Kele, J., & Blomgren, K. (2020). Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain. Cell reports, 31(9), Article 107699. https://doi.org/10.1016/j.celrep.2020.107699

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title = "Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain",

abstract = "Osman et al. show that microglia undergo transient changes after radiation, displaying a series of temporally distinct molecular signatures with a trajectory toward baseline within one week and suggesting a narrow time window for any therapeutic interventions specifically targeting early microglial activation after irradiation.",

keywords = "M1 and M2, RNA sequencing, neuroinflammation, radiotherapy, transcriptome",

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AU - Osman, Ahmed M.

AU - Sun, Ying

AU - Burns, Terry C.

AU - He, Liqun

AU - Kee, Nigel

AU - Oliva-Vilarnau, Nuria

AU - Alevyzaki, Androniki

AU - Zhou, Kai

AU - Louhivuori, Lauri

AU - Uhlén, Per

AU - Hedlund, Eva

AU - Betsholtz, Christer

AU - Lauschke, Volker M.

AU - Kele, Julianna

AU - Blomgren, Klas

PY - 2020/6/2

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KW - RNA sequencing

KW - neuroinflammation

KW - radiotherapy

KW - transcriptome

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Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Abstract

Keywords

ASJC Scopus subject areas

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