Radiation therapy strategies for skull-base malignancies

J. D. Palmer, M. E. Gamez, K. Ranta, H. Ruiz-Garcia, J. L. Peterson, D. M. Blakaj, D. Prevedello, R. Carrau, A. Mahajan, K. L. Chaichana, D. M. Trifiletti

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Introduction: The management of skull base malignancies continues to evolve with improvements in surgical technique, advances in radiation delivery and novel systemic agents. Methods: In this review, we aim to discuss in detail the management of common skull base pathologies which typically require multimodality therapy, focusing on the radiotherapeutic aspects of care. Results: Technological advances in the administration of radiation therapy have led to a wide variety of different treatment strategies for the treatment of skull base malignances, with outcomes summarized herein. Conclusion: Radiation treatment plays a key and critical role in the management of patients with skull base tumors. Recent advancements continue to improve the risk/benefit ratio for radiotherapy in this setting.

Original languageEnglish (US)
Pages (from-to)445-462
Number of pages18
JournalJournal of neuro-oncology
Issue number3
StatePublished - Dec 2020


  • Gamma knife radiosurgery
  • Intensity modulated proton therapy
  • Intensity modulated radiation therapy
  • Proton therapy
  • Radiation
  • Skull base
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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