Radiation-induced cell death and dendritic cells: Potential for cancer immunotherapy?

Paul Hatfield., A. Merrick, K. Harrington, R. Vile, A. Bateman, A. Selby, A. Melcher

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Dendritic cells are key orchestrators of the immune system. There is considerable interest in their use for treating cancer. Whether they initiate an effective cytotoxic response against antigen-bearing cells, or produce tolerance, depends on the context in which those antigens are presented. Ionising radiation, and the cell death it causes, has several properties that may facilitate such an effective response. A range of in-vitro and in-vivo data supports this, although potential problems exist that may require concurrent strategies.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalClinical Oncology
Issue number1
StatePublished - Feb 2005


  • Apoptosis
  • Cell death
  • Dendritic cells
  • Immunotherapy
  • Ionising radiation
  • Necrosis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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