Radiation field design in the ACOSOG Z0011 (Alliance) trial

Reshma Jagsi, Manjeet Chadha, Janaki Moni, Karla Ballman, Fran Laurie, Thomas A. Buchholz, Armando Giuliano, Bruce G. Haffty

Research output: Contribution to journalArticlepeer-review

205 Scopus citations


Purpose: ACOSOG Z0011 established that axillary lymph node dissection (ALND) is unnecessary in patients with breast cancer with one to two positive sentinel lymph nodes (SLNs) who undergo umpectomy, radiotherapy (RT), and systemic therapy. We sought to ascertain RT coverage of the regional nodes in that trial.

Methods: We evaluated case report forms completed 18 months after enrollment. From 2012 to 2013, we collected all available detailed RT records for central review.

Results: Among 605 patients with completed case report forms, 89% received whole-breast RT. Of these, 89 (15%) were recorded as also receiving treatment to the supraclavicular region. Detailed RT records were obtained for 228 patients, of whom 185 (81. 1%) received tangent-only treatment Among 142 with sufficient records to evaluate tangent height, high tangents (cranial tangent border ≤ 2 cm from humeral head) were used in 50% of patients (33 of 66) randomly assigned to ALND and 52. 6% (40 of 76) randomly assigned to SLND. Of the 228 patients with records reviewed, 43 (18. 9%) received directed regional nodal RT using ≥ three fields: 22 in the ALND arm and 21 in the SLND arm. Those receiving directed nodal RT had greater nodal involvement (P < 001) than those who did not. Overall, there was no significant difference between treatment arms in the use of protocol-prohibited nodal fields.

Conclusion: Most patients treated in Z0011 received tangential RT alone, and some received no RT at all. Some patients received directed nodal irradiation via a third field. Further research is necessary to determine the optimal RT approach in patients with low-volume axillary disease treated with SLND alone.

Original languageEnglish (US)
Pages (from-to)3600-3606
Number of pages7
JournalJournal of Clinical Oncology
Issue number32
StatePublished - Nov 10 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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