Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J. Lincoln, Owen A. Ross, Nicole M. Milkovic, Dennis W. Dickson, Alex Rajput, Christopher A. Robinson, Spiridon Papapetropoulos, Deborah C. Mash, Matthew J. Farrer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

Original languageEnglish (US)
Pages (from-to)340-342
Number of pages3
JournalParkinsonism and Related Disorders
Issue number6
StatePublished - Aug 2007


  • Genomic multiplication
  • Multiple system atrophy
  • Quantitative PCR
  • α-Synuclein

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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