TY - JOUR
T1 - Quantitative magnetic resonance imaging for chronic liver disease
AU - Cunha, Guilherme Moura
AU - Navin, Patrick J.
AU - Fowler, Kathryn J.
AU - Venkatesh, Sudhakar K.
AU - Ehman, Richard L.
AU - Sirlin, Claude B.
N1 - Publisher Copyright:
© 2021 The Authors. Published by the British Institute of Radiology
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Chronic liver disease (CLD) has rapidly increased in prevalence over the past two decades, resulting in significant morbidity and mortality worldwide. Historically, the clinical gold standard for diagnosis, assessment of severity, and longitudinal monitoring of CLD has been liver biopsy with histological analysis, but this approach has limitations that may make it suboptimal for clinical and research settings. Magnetic resonance (MR)-based biomarkers can overcome the limitations by allowing accurate, precise, and quantitative assessment of key components of CLD without the risk of invasive procedures. This review briefly describes the limitations associated with liver biopsy and the need for non-invasive biomarkers. It then discusses the current state-of-the-art for MRI-based biomarkers of liver iron, fat, and fibrosis, and inflammation.
AB - Chronic liver disease (CLD) has rapidly increased in prevalence over the past two decades, resulting in significant morbidity and mortality worldwide. Historically, the clinical gold standard for diagnosis, assessment of severity, and longitudinal monitoring of CLD has been liver biopsy with histological analysis, but this approach has limitations that may make it suboptimal for clinical and research settings. Magnetic resonance (MR)-based biomarkers can overcome the limitations by allowing accurate, precise, and quantitative assessment of key components of CLD without the risk of invasive procedures. This review briefly describes the limitations associated with liver biopsy and the need for non-invasive biomarkers. It then discusses the current state-of-the-art for MRI-based biomarkers of liver iron, fat, and fibrosis, and inflammation.
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U2 - 10.1259/bjr.20201377
DO - 10.1259/bjr.20201377
M3 - Review article
C2 - 33635729
AN - SCOPUS:85105691823
SN - 0007-1285
VL - 94
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1121
M1 - 20201377
ER -