Quantitative magnetic resonance imaging for chronic liver disease

Guilherme Moura Cunha, Patrick J. Navin, Kathryn J. Fowler, Sudhakar K. Venkatesh, Richard L. Ehman, Claude B. Sirlin

Research output: Contribution to journalReview articlepeer-review


Chronic liver disease (CLD) has rapidly increased in prevalence over the past two decades, resulting in significant morbidity and mortality worldwide. Historically, the clinical gold standard for diagnosis, assessment of severity, and longitudinal monitoring of CLD has been liver biopsy with histological analysis, but this approach has limitations that may make it suboptimal for clinical and research settings. Magnetic resonance (MR)-based biomarkers can overcome the limitations by allowing accurate, precise, and quantitative assessment of key components of CLD without the risk of invasive procedures. This review briefly describes the limitations associated with liver biopsy and the need for non-invasive biomarkers. It then discusses the current state-of-the-art for MRI-based biomarkers of liver iron, fat, and fibrosis, and inflammation.

Original languageEnglish (US)
Article number20201377
JournalBritish Journal of Radiology
Issue number1121
StatePublished - May 1 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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