Quantitative characterization of brain β-amyloid using a joint PiB/FDG PET image histogram

Jon J. Camp, Dennis P. Hanson, David R. Holmes, Bradley J. Kemp, Matthew L. Senjem, Melissa E. Murray, Dennis W. Dickson, Joseph E. Parisi, Ronald C. Petersen, Val J. Lowe, Richard A. Robb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


A complex analysis performed by spatial registration of PiB and MRI patient images in order to localize the PiB signal to specific cortical brain regions has been proven effective in identifying imaging characteristics associated with underlying Alzheimera's Disease (AD) and Lewy Body Disease (LBD) pathology. This paper presents an original method of image analysis and stratification of amyloid-related brain disease based on the global spatial correlation of PiB PET images with 18F-FDG PET images (without MR images) to categorize the PiB signal arising from the cortex. Rigid registration of PiB and 18F-FDG images is relatively straightforward, and in registration the 18F-FDG signal serves to identify the cortical region in which the PiB signal is relevant. Cortical grey matter demonstrates the highest levels of amyloid accumulation and therefore the greatest PiB signal related to amyloid pathology. The highest intensity voxels in the 18F-FDG image are attributed to the cortical grey matter. The correlation of the highest intensity PiB voxels with the highest 18F-FDG values indicates the presence of I-amyloid protein in the cortex in disease states, while correlation of the highest intensity PiB voxels with mid-range 18F-FDG values indicates only nonspecific binding in the white matter.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationComputer-Aided Diagnosis
ISBN (Print)9780819498281
StatePublished - 2014
EventMedical Imaging 2014: Computer-Aided Diagnosis - San Diego, CA, United States
Duration: Feb 18 2014Feb 20 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2014: Computer-Aided Diagnosis
Country/TerritoryUnited States
CitySan Diego, CA


  • Alzheimer's disease
  • Joint histogram
  • Lewy body disease
  • PET imaging
  • PiB
  • β-amyloid plaques

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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