Quantitative analysis of flow behavior of carotid plaque neovasculature

Assaf Hoogi, Johan G. Bosch, Zeynettin Akkus, Gerrit L. Ten Kate, Stijn C.H. Van Den Oord, Arend F.L. Schinkel, Nico De Jong, Dan Adam, Antonius F.W. Van Der Steen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Intra-plaque neovascularization is considered to be an important indication for plaque vulnerability. We propose a semi-automatic algorithm that may supply quantitative analysis of neovasculature and reconstruction of its tree, thus enabling assessment of plaque vulnerability. An algorithm for automatic contrast spot detection and for tracking these spots using Multidimensional Dynamic Programming was developed to map the intra-plaque neovascularization. Classification of contrast tracks into blood vessels and artifacts was performed, based on their motion pattern characteristics. Seventy-three different contrast spots in 25 plaques were visually identified. The automatic contrast spot detection method found 70of these objects. In 65 objects the automatic tracking determined the contrast motion correctly. In addition, the objects were correctly classified in 89% of the cases. These results show that the method can successfully quantify features that are linked to vulnerability of the carotid plaque.

Original languageEnglish (US)
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Number of pages4
StatePublished - 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2011 IEEE International Ultrasonics Symposium, IUS 2011
Country/TerritoryUnited States
CityOrlando, FL


  • Carotid plaque
  • Neovascularization
  • Quantitative analysis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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