Abstract
Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies.
Original language | English (US) |
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Pages (from-to) | 106-120 |
Number of pages | 15 |
Journal | Clinical Immunology |
Volume | 120 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2006 |
Keywords
- B cells
- Clone
- Human
- Immunoglobulin light chain amyloidosis
- Monoclonal gammopathy
- Plasma cell dyscrasia
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology