Quantification of myocardial perfusion by MRI after coronary occlusion

Jean Paul M. Vallée, H. Dirk Sostman, James R. MacFall, Timothy R. DeGrado, Jian Zhang, Laurent Sebbag, Fred R. Cobb, Ted Wheeler, Larry W. Hedlund, Timothy G. Turkington, Charles E. Spritzer, R. Edward Coleman

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

Original languageEnglish (US)
Pages (from-to)287-297
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - Aug 1998


  • Blood flow
  • Magnetic resonance imaging
  • Myocardial infarction
  • Radioisotopes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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