Quality of life after ileal pouch-anal anastomosis and ileorectal anastomosis in patients with familial adenomatous polyposis

Imran Hassan, Heidi K. Chua, Bruce G. Wolff, Stephanie F. Donnelly, Roger R. Dozois, Dirk R. Larson, Cathy D. Schleck, Heidi Nelson

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


PURPOSE: Differences in conventional outcomes such as functional results and the rate of complications have caused a controversy about whether the ileal pouch anal anastomosis or the ileorectal anastomosis is the preferred surgical treatment for patients with familial adenomatous polyposis. We therefore sought to ascertain not only the surgical results but also the perceptions of patients about their outcomes. METHODS: Between 1981 and 1998, 152 patients at our institution had an ileal pouch-anal anastomosis and 32 patients had an ileorectal anastomosis for familial adenomatous polyposis. Of these 184 patients, 173 were sent a study-specific quality-of-life questionnaire and the Short Form 36 health survey to determine their health-related quality of life. RESULTS: Ninety-four ileal pouch patients and 21 ileorectal patients returned the surveys. No difference was found in early postoperative complications, 5-year probability for complications, or functional results after either procedure. On the Short Form 36 health survey, the ileorectal patients had a lower mental health summary score compared with that of the ileal pouch patients but a similar physical health summary score. The study-specific questionnaire found both groups to have a comparable quality of life. CONCLUSION: Because ileal pouch-anal anastomosis has the advantage of removing as much at-risk tissue as possible with similar functional results and better mental health, it may be considered the preferred operation for most patients with familial adenomatous polyposis.

Original languageEnglish (US)
Pages (from-to)2032-2037
Number of pages6
JournalDiseases of the colon and rectum
Issue number11
StatePublished - Nov 2005


  • Adenomatous polyposis coli
  • Ileal pouch-anal anastomosis
  • Ileorectal anastomosis
  • Quality of life

ASJC Scopus subject areas

  • Gastroenterology


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