Pulsatility of hypothalamo-pituitary hormones: A challenge in quantification

Daniel M. Keenan, Johannes D. Veldhuis

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.

Original languageEnglish (US)
Pages (from-to)34-50
Number of pages17
Issue number1
StatePublished - Jan 2016

ASJC Scopus subject areas

  • Physiology


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