Proximity of the Mep-1 Gene to H-2D on chromosome 17 in mice

Jane F. Reckelhoff, Judith S. Bond, Robert J. eynon, S. Savarirayan, Chella S. David

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1ballele. Mouse strains in which meprin activity levels are normal are designated Mep-1a Studies using congenic and recombinant strains mapped the Mep-1 gene telomeric to H-2D near the Tla gene. To further study the relationship between the major histocompatibility complex and Mep-1, a linkage study was conducted. Mep-1a F1 hybrids [C3H.A (KkDd) × C3H.OH (KdDk)] were backcrossed with Mep-1b C3H.OH (KdDk) parents. The progeny were assayed for H-2D markers, Pgk-2 isozymes, and meprin activity. Recombination between H-2D and Mep-1 occurred in 6 out of 284 mice, a crossover frequency of 2.1%. Mep-1 is therefore 2.1 crossover units telomeric to H-2D and approximately 0.6 crossover units from Tla. The Mep-1 locus provides a new genetic marker for the future mapping of this important area of the mouse genome.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
Issue number6
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Immunology
  • Genetics


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