Proton MR spectroscopy in aging and dementia

Research output: Chapter in Book/Report/Conference proceedingChapter


Introduction Neuroimaging techniques may have an important role in the clinical evaluation of dementia for early diagnosis, differential diagnosis, and monitoring of disease activity. The goal of this chapter is to review proton MR spectroscopy (MRS) literature in aging and dementia in order to demonstrate the potential clinical applications of the technique. Normal aging Age related changes in proton MRS measurements of the metabolites N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myo-inositol (mI) were investigated by several groups, and the results have been conflicting. There are reports showing that metabolite measurements are stable throughout aging;[1] one study showed a decrease in NAA, Cho, and Cr in gray matter,[2] and others an increase in Cho and Cr in the gray matter and white matter with aging.[3-7] As a whole, most studies agree that Cho and Cr increase with aging, and a majority of the studies agree that NAA levels are stable throughout aging (Table 39.1).

Original languageEnglish (US)
Title of host publicationClinical MR Neuroimaging
Subtitle of host publicationPhysiological and Functional Techniques, Second Edition
PublisherCambridge University Press
Number of pages10
ISBN (Electronic)9781139193481
ISBN (Print)9780521515634
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • General Medicine


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