Protein kinase Cι: A versatile oncogene in the lung

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1 Scopus citations


We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Original languageEnglish (US)
Article numbere1190886
JournalMolecular and Cellular Oncology
Issue number5
StatePublished - Sep 3 2018


  • Gene amplification
  • Protein Kinase Ciota
  • lung adenocarcinoma
  • lung squamous cell carcinoma
  • non-small cell lung cancer
  • therapeutic targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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