Prostaglandin release following Nd:YAG iridotomy in rabbits

R. Gailitis, G. A. Peyman, J. Pulido, M. D. Mitchell, R. M. Weinreb

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In this study, iridotomies were performed in nine rabbit eyes using an Nd:YAG laser at 5.2 mJ, three pulses/burst, for one burst. Prostaglandin E2 (PGE2) in aqueous humor obtained at timed intervals after treatment was then measured using a sensitive and specific radioimmunoassay. Concentrations of PGE2 (mean ± SD pg/ml) were: pretreatment, 377±89; 30 minutes, 1858±241; 120 minutes, 735±308; and 240 minutes, 401±59, postoperatively. The release of PGE2 into the aqueous humor parallels the rise in intraocular pressure following Nd:YAG iridotomies in rabbits and thus may contribute to this phenomenon.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalOphthalmic Surgery
Issue number8
StatePublished - 1986

ASJC Scopus subject areas

  • Ophthalmology


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