Prospective evaluation of low-dose warfarin for prevention of thalidomide associated venous thromboembolism

Kena C. Miller; Swaminathan Padmanabhan; Laurie Dimicelli; Dawn Depaolo; Beverly Landrigan; Jihnhee Yu; Virginia Doran; Patricia Marshal; Asher Chanan-Khan

doi:10.1080/10428190600799631

Prospective evaluation of low-dose warfarin for prevention of thalidomide associated venous thromboembolism

Kena C. Miller, Swaminathan Padmanabhan, Laurie Dimicelli, Dawn Depaolo, Beverly Landrigan, Jihnhee Yu, Virginia Doran, Patricia Marshal, Asher Chanan-Khan

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Venous thromboemobolism (VTE) is an important complication of thalidomide therapy especially when it is combined with steroids or chemotherapy. Currently there is no consensus on the most appropriate prophylactic approach. We prospectively investigated the use of low-dose warfarin sodium in prevention of thalidomide-associated VTE in patients receiving thalidomide-based combination therapies. Patients with multiple myeloma or chronic lymphocytic leukemia who were treated on thalidomide based-combination therapies were treated on low-dose warfarin (1 or 2 mg) continuously through the duration of their therapy. Among the 68 patients enrolled, four developed an episode of VTE, an overall incidence of 5.9% (odds = 0.063). Median duration of thalidomide therapy was 4 months. Low-does warfarin decreases the incidence of VTE compared to historical control and is an effective mechanism of prevention of VTE in thalidomide-based chemotherapy regimens.

Original language	English (US)
Pages (from-to)	2339-2343
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	47
Issue number	11
DOIs	https://doi.org/10.1080/10428190600799631
State	Published - Nov 2006

Keywords

Leukemia
Thalidomide
Thromboemobolism
Warfarin

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190600799631

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title = "Prospective evaluation of low-dose warfarin for prevention of thalidomide associated venous thromboembolism",

abstract = "Venous thromboemobolism (VTE) is an important complication of thalidomide therapy especially when it is combined with steroids or chemotherapy. Currently there is no consensus on the most appropriate prophylactic approach. We prospectively investigated the use of low-dose warfarin sodium in prevention of thalidomide-associated VTE in patients receiving thalidomide-based combination therapies. Patients with multiple myeloma or chronic lymphocytic leukemia who were treated on thalidomide based-combination therapies were treated on low-dose warfarin (1 or 2 mg) continuously through the duration of their therapy. Among the 68 patients enrolled, four developed an episode of VTE, an overall incidence of 5.9% (odds = 0.063). Median duration of thalidomide therapy was 4 months. Low-does warfarin decreases the incidence of VTE compared to historical control and is an effective mechanism of prevention of VTE in thalidomide-based chemotherapy regimens.",

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AU - Padmanabhan, Swaminathan

AU - Dimicelli, Laurie

AU - Depaolo, Dawn

AU - Landrigan, Beverly

AU - Yu, Jihnhee

AU - Doran, Virginia

AU - Marshal, Patricia

AU - Chanan-Khan, Asher

PY - 2006/11

Y1 - 2006/11

N2 - Venous thromboemobolism (VTE) is an important complication of thalidomide therapy especially when it is combined with steroids or chemotherapy. Currently there is no consensus on the most appropriate prophylactic approach. We prospectively investigated the use of low-dose warfarin sodium in prevention of thalidomide-associated VTE in patients receiving thalidomide-based combination therapies. Patients with multiple myeloma or chronic lymphocytic leukemia who were treated on thalidomide based-combination therapies were treated on low-dose warfarin (1 or 2 mg) continuously through the duration of their therapy. Among the 68 patients enrolled, four developed an episode of VTE, an overall incidence of 5.9% (odds = 0.063). Median duration of thalidomide therapy was 4 months. Low-does warfarin decreases the incidence of VTE compared to historical control and is an effective mechanism of prevention of VTE in thalidomide-based chemotherapy regimens.

AB - Venous thromboemobolism (VTE) is an important complication of thalidomide therapy especially when it is combined with steroids or chemotherapy. Currently there is no consensus on the most appropriate prophylactic approach. We prospectively investigated the use of low-dose warfarin sodium in prevention of thalidomide-associated VTE in patients receiving thalidomide-based combination therapies. Patients with multiple myeloma or chronic lymphocytic leukemia who were treated on thalidomide based-combination therapies were treated on low-dose warfarin (1 or 2 mg) continuously through the duration of their therapy. Among the 68 patients enrolled, four developed an episode of VTE, an overall incidence of 5.9% (odds = 0.063). Median duration of thalidomide therapy was 4 months. Low-does warfarin decreases the incidence of VTE compared to historical control and is an effective mechanism of prevention of VTE in thalidomide-based chemotherapy regimens.

KW - Leukemia

KW - Thalidomide

KW - Thromboemobolism

KW - Warfarin

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Prospective evaluation of low-dose warfarin for prevention of thalidomide associated venous thromboembolism

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Keywords

ASJC Scopus subject areas

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