Abstract
A growing number of monoclonal gammopathy-associated kidney diseases recently have been recognized. We present the case of a 54-year-old man who presented with acute kidney injury and hypocomplementemia. Kidney biopsy confirmed the presence of immunoglobulin G κ pseudothrombi with intracytoplasmic crystals in glomeruli and tubules. Levels of κ free light chains were elevated without a detectable monoclonal gammopathy, and bone marrow biopsy results were normal. After the first course of rituximab, cyclophosphamide, and dexamethasone in addition to daily plasmapheresis, kidney function recovered within 2 weeks and dialysis therapy was discontinued. Treatment for monoclonal protein-induced kidney disease should be considered in the setting of progressive decreased kidney function, even in the absence of a circulating monoclonal protein or cellular clone of origin.
Original language | English (US) |
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Pages (from-to) | 994-998 |
Number of pages | 5 |
Journal | American Journal of Kidney Diseases |
Volume | 64 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2014 |
Keywords
- Kidney failure
- glomerulonephritis
- monoclonal protein
ASJC Scopus subject areas
- Nephrology