Proliferative glomerulonephritis due to monoclonal deposition with organized substructures

Abdurrahman M. Hamadah, Mira T. Keddis, Lynn D. Cornell, Nelson Leung

Research output: Contribution to journalArticlepeer-review


A growing number of monoclonal gammopathy-associated kidney diseases recently have been recognized. We present the case of a 54-year-old man who presented with acute kidney injury and hypocomplementemia. Kidney biopsy confirmed the presence of immunoglobulin G κ pseudothrombi with intracytoplasmic crystals in glomeruli and tubules. Levels of κ free light chains were elevated without a detectable monoclonal gammopathy, and bone marrow biopsy results were normal. After the first course of rituximab, cyclophosphamide, and dexamethasone in addition to daily plasmapheresis, kidney function recovered within 2 weeks and dialysis therapy was discontinued. Treatment for monoclonal protein-induced kidney disease should be considered in the setting of progressive decreased kidney function, even in the absence of a circulating monoclonal protein or cellular clone of origin.

Original languageEnglish (US)
Pages (from-to)994-998
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number6
StatePublished - Dec 1 2014


  • Kidney failure
  • glomerulonephritis
  • monoclonal protein

ASJC Scopus subject areas

  • Nephrology


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