ProLiferative and Preneoplastic Lesions of the Breast

D. W. Visscher

Research output: Chapter in Book/Report/Conference proceedingChapter


This article summarizes the histological forms of benign and atypical pathology that are encountered in breast biopsy material, including open surgical excisions and needle cores. It is focused particularly on lesions that are difficult to distinguish from maLignancy, owing to histological mimicry caused by high levels of cellularity and/or architectural complexity. These topics include papilloma, sclerosing lesions, secretory lesions, and columnar alteration in addition to atypical ductal hyperplasia and atypical lobular hyperplasia. The text is heavily focused on providing key definitional characteristics and providing specific microscopic criteria that are useful in distinguishing between problematic examples. The level of future breast cancer risk attributable to various entities is described. Finally, current practice regarding cLinical management of various lesions is reviewed.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Number of pages14
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
StatePublished - Jan 1 2014


  • Atypical ductal hyperplasia
  • Atypical lobular hyperplasia
  • Columnar alteration of lobules
  • Ductal carcinoma in situ
  • Flat epitheLial atypia
  • Intraductal papilloma
  • Lobular carcinoma in situ
  • Mucocele-Like tumor
  • Papillary carcinoma
  • Radial scar
  • Sclerosing adenosis
  • Secretory change
  • Usual ductal hyperplasia

ASJC Scopus subject areas

  • General Medicine


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