Prolactin suppression of leukocyte chemotaxis in vitro

R. D. Harris, N. E. Kay, E. L. Seljeskog, K. J. Murray, S. D. Douglas

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Leukocyte chemotaxis in vitro was studied for cells from patients with pituitary adenomas. Leukocytes obtained preoperatively from two of three patients with elevated serum prolactin levels demonstrated chemotaxic alterations described in other malignant disease. Statistically significant suppression of chemotaxis occurred in the leukocytes of four of 12 specimens from normal donors at concentrations of 1000 ng/ml, and in four of eight specimens at 2000 ng/ml of prolactin in preincubation media. Thus prolactin concentration may influence the motility of leukocytes. The variable neoplastic behavior of morphologically similar pituitary adenomas may, in part, reflect a neurohormonally altered host response to the presence of these lesions.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalUnknown Journal
Issue number4
StatePublished - 1979

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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