Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy

Terence J. O'Brien, Elson L. So, Fredrick B. Meyer, Joseph E. Parisi, Clifford R. Jack

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.

Original languageEnglish (US)
Pages (from-to)526-529
Number of pages4
JournalAnnals of neurology
Issue number4
StatePublished - 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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