TY - JOUR
T1 - Progression of dysautonomia in multiple system atrophy
T2 - A prospective study of self-perceived impairment
AU - Köllensperger, M.
AU - Stampfer-Kountchev, M.
AU - Seppi, K.
AU - Geser, F.
AU - Frick, C.
AU - Del Sorbo, F.
AU - Albanese, A.
AU - Gurevich, T.
AU - Giladi, N.
AU - Djaldetti, R.
AU - Schrag, A.
AU - Low, P. A.
AU - Mathias, C. J.
AU - Poewe, W.
AU - Wenning, G. K.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - To assess severity and progression of self-perceived dysautonomia and their impact on health-related quality of life (Hr-QoL) in multiple system atrophy (MSA), twenty-seven patients were recruited by the European MSA Study Group (EMSA-SG). At baseline, all patients completed the Composite Autonomic Symptom Scale (COMPASS) and the 36 item Short Form Health Survey (SF-36), and they were assessed using the 3-point global disease severity scale (SS-3) and the Unified MSA Rating Scale (UMSARS). After 6 months follow-up, the self completed COMPASS Change Scale (CCS), the SF-36, SS-3, and UMSARS were obtained. MSA patients showed marked self-perceived dysautonomia at baseline visit and pronounced worsening of dysautonomia severity on the CCS at follow-up. Severity and progression of dysautonomia did not correlate with age, disease duration, motor impairment and overall disease severity at baseline. There were no significant differences between genders and motor subtypes. Baseline COMPASS scores were, however, inversely correlated with SF-36 scores. Progression of self-perceived dysautonomia did not correlate with global disease progression. Hr-QoL scores were stable during follow-up. This is the first study to investigate self-perceived dysautonomia severity in MSA and its evolution over time. Our data suggest that dysautonomia should be recognized as a key target for therapeutic intervention in MSA.
AB - To assess severity and progression of self-perceived dysautonomia and their impact on health-related quality of life (Hr-QoL) in multiple system atrophy (MSA), twenty-seven patients were recruited by the European MSA Study Group (EMSA-SG). At baseline, all patients completed the Composite Autonomic Symptom Scale (COMPASS) and the 36 item Short Form Health Survey (SF-36), and they were assessed using the 3-point global disease severity scale (SS-3) and the Unified MSA Rating Scale (UMSARS). After 6 months follow-up, the self completed COMPASS Change Scale (CCS), the SF-36, SS-3, and UMSARS were obtained. MSA patients showed marked self-perceived dysautonomia at baseline visit and pronounced worsening of dysautonomia severity on the CCS at follow-up. Severity and progression of dysautonomia did not correlate with age, disease duration, motor impairment and overall disease severity at baseline. There were no significant differences between genders and motor subtypes. Baseline COMPASS scores were, however, inversely correlated with SF-36 scores. Progression of self-perceived dysautonomia did not correlate with global disease progression. Hr-QoL scores were stable during follow-up. This is the first study to investigate self-perceived dysautonomia severity in MSA and its evolution over time. Our data suggest that dysautonomia should be recognized as a key target for therapeutic intervention in MSA.
KW - Composite Autonomic Symptom Scale
KW - Dysautonomia
KW - Health-related quality of life
KW - Multiple system atrophy
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U2 - 10.1111/j.1468-1331.2006.01554.x
DO - 10.1111/j.1468-1331.2006.01554.x
M3 - Article
C2 - 17222116
AN - SCOPUS:33846179348
SN - 1351-5101
VL - 14
SP - 66
EP - 72
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 1
ER -