Progress on new vaccine strategies against chronic viral infections

Jay A. Berzofsky, Jeffrey D. Ahlers, John Janik, John Morris, Sang Kon Oh, Masaki Terabe, Igor M. Belyakov

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for die vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses - quantitative and qualitative - than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.

Original languageEnglish (US)
Pages (from-to)450-462
Number of pages13
JournalJournal of Clinical Investigation
Issue number4
StatePublished - Aug 2004

ASJC Scopus subject areas

  • General Medicine


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