TY - JOUR
T1 - Progress on new vaccine strategies against chronic viral infections
AU - Berzofsky, Jay A.
AU - Ahlers, Jeffrey D.
AU - Janik, John
AU - Morris, John
AU - Oh, Sang Kon
AU - Terabe, Masaki
AU - Belyakov, Igor M.
PY - 2004/8
Y1 - 2004/8
N2 - Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for die vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses - quantitative and qualitative - than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.
AB - Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for die vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses - quantitative and qualitative - than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.
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U2 - 10.1172/JCI200422674
DO - 10.1172/JCI200422674
M3 - Review article
C2 - 15314679
AN - SCOPUS:4344686181
SN - 0021-9738
VL - 114
SP - 450
EP - 462
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -