Progress on Management of Penile Cancer in 2020

Mohamed E. Ahmed, Mahmoud I. Khalil, Mohamed H. Kamel, R. Jeffrey Karnes, Philippe E. Spiess

Research output: Contribution to journalReview articlepeer-review


Management of penile cancer represents a challenge to urologic oncologists due to the disease’s rarity and sparse data in the literature. Squamous cell carcinoma represents the most common histologic subtype of penile cancer. Penile cancer has a disastrous effect on patients’ psychological and physical health. Penile cancer accounts for approximately 1% of cancer deaths in the USA annually. However, in recent years, the management of penile cancer has achieved marked progress in both diagnostic and therapeutic approaches with the intent to avoid radical surgeries. The traditional total penile amputation has been replaced by penile preserving procedures in many patients. Nowadays, total penile amputation (total penectomy) is preserved only for patients with proximal lesions. The introduction of minimally invasive surgical techniques in the management of penile cancer-infiltrated lymph nodes has been reported. Given the dismal prognosis with conventional cytotoxic therapies, new systemic therapies have been investigated in patients with locally advanced or metastatic penile cancer. Multiple studies have shown promising outcomes. All these efforts have resulted in a remarkable improvement in patient quality of life. The objectives of our review are to update clinicians on the advances in the management of penile cancer and to summarize the recent guidelines and recommendations.

Original languageEnglish (US)
Article number4
JournalCurrent treatment options in oncology
Issue number1
StatePublished - Jan 2021


  • Advanced penile cancer
  • Diagnosis
  • Early penile cancer
  • Metastatic
  • Risk factors
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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