Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma

Sibo Tian; Matthew J. Ferris; Jeffrey M. Switchenko; Kelly R. Magliocca; Richard J. Cassidy; Jaymin Jhaveri; Ashley H. Aiken; Kristen L. Baugnon; Patricia A. Hudgins; Ayse T.K. Kendi; Mihir R. Patel; Nabil F. Saba; Walter J. Curran; Jonathan J. Beitler

doi:10.1002/hed.25791

Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma

Sibo Tian, Matthew J. Ferris, Jeffrey M. Switchenko, Kelly R. Magliocca, Richard J. Cassidy, Jaymin Jhaveri, Ashley H. Aiken, Kristen L. Baugnon, Patricia A. Hudgins, Ayse T.K. Kendi, Mihir R. Patel, Nabil F. Saba, Walter J. Curran, Jonathan J. Beitler

Radiology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. Results: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. Conclusions: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.

Original language	English (US)
Pages (from-to)	3056-3063
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	9
DOIs	https://doi.org/10.1002/hed.25791
State	Published - Sep 2019

Keywords

ENE
HPV
extranodal extension
oropharynx cancer
p16

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25791

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Tian, S., Ferris, M. J., Switchenko, J. M., Magliocca, K. R., Cassidy, R. J., Jhaveri, J., Aiken, A. H., Baugnon, K. L., Hudgins, P. A., Kendi, A. T. K., Patel, M. R., Saba, N. F., Curran, W. J., & Beitler, J. J. (2019). Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma. Head and Neck, 41(9), 3056-3063. https://doi.org/10.1002/hed.25791

Tian, S, Ferris, MJ, Switchenko, JM, Magliocca, KR, Cassidy, RJ, Jhaveri, J, Aiken, AH, Baugnon, KL, Hudgins, PA, Kendi, ATK, Patel, MR, Saba, NF, Curran, WJ & Beitler, JJ 2019, 'Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma', Head and Neck, vol. 41, no. 9, pp. 3056-3063. https://doi.org/10.1002/hed.25791

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title = "Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma",

abstract = "Background: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. Results: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. Conclusions: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.",

keywords = "ENE, HPV, extranodal extension, oropharynx cancer, p16",

author = "Sibo Tian and Ferris, {Matthew J.} and Switchenko, {Jeffrey M.} and Magliocca, {Kelly R.} and Cassidy, {Richard J.} and Jaymin Jhaveri and Aiken, {Ashley H.} and Baugnon, {Kristen L.} and Hudgins, {Patricia A.} and Kendi, {Ayse T.K.} and Patel, {Mihir R.} and Saba, {Nabil F.} and Curran, {Walter J.} and Beitler, {Jonathan J.}",

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year = "2019",

month = sep,

doi = "10.1002/hed.25791",

language = "English (US)",

volume = "41",

pages = "3056--3063",

journal = "Head and Neck",

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T1 - Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma

AU - Tian, Sibo

AU - Ferris, Matthew J.

AU - Switchenko, Jeffrey M.

AU - Magliocca, Kelly R.

AU - Cassidy, Richard J.

AU - Jhaveri, Jaymin

AU - Aiken, Ashley H.

AU - Baugnon, Kristen L.

AU - Hudgins, Patricia A.

AU - Kendi, Ayse T.K.

AU - Patel, Mihir R.

AU - Saba, Nabil F.

AU - Curran, Walter J.

AU - Beitler, Jonathan J.

PY - 2019/9

Y1 - 2019/9

N2 - Background: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. Results: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. Conclusions: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.

AB - Background: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. Results: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. Conclusions: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.

KW - ENE

KW - HPV

KW - extranodal extension

KW - oropharynx cancer

KW - p16

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Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma

Abstract

Keywords

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