Prognostic factors associated with congenital cystic adenomatoid malformation of the lung

Victor Bunduki, Rodrigo Ruano, Marcos Marques Da Silva, Javier Miguelez, Seizo Miyadahira, João Gilberto Maksoud, Marcelo Zugaib

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


This study presents 18 cases of prenatally diagnosed congenital cystic adenomatoid malformation (CCAM) to identify potential factors that could predict prognosis. Comparisons of prenatal parameters were made between fetuses that survived and those that died perinatally. It was found that microcystic lesion, bilateral lung involvement and hydrops were each highly correlated with poor prognosis, while neither polyhydramnios nor mediastinal shift was significantly associated with bad outcome. Fetal interventions were indicated only in two of the surviving cases: a thoracocentesis and a cysto-amniotic shunt. A therapeutic amniocentesis was performed in one case of polyhydramnios. The diagnosis of CCAM was histologically confirmed in all cases by necropsy or by postnatal lobectomy. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalPrenatal Diagnosis
Issue number6
StatePublished - Jul 3 2000


  • Cystic adenomatoid malformation
  • Fetal therapy
  • Prenatal diagnosis
  • Ultrasonography

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)


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