Prognosis of children with solitary kidney after unilateral nephrectomy

L. R. Argueso, M. L. Ritchey, E. T. Boyle, D. S. Milliner, E. J. Bergstralh, S. A. Kramer

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The clinical course of 138 children who underwent unilateral nephrectomy and had a normal contralateral kidney at the time of nephrectomy was reviewed. The diagnosis leading to nephrectomy included obstructive uropathy in 46% of the cases, reflux or pyelonephritis in 30%, Wilms tumor in 15%, hypertension in 4%, dysplastic kidney in 2% and trauma in 2%. Mean age at nephrectomy was 7.3 years and median followup was 24.7 years. Of the 138 patients 121 (88%) are well and 17 died, including 14 secondary to metastatic Wilms tumor and 1 of renal failure. Survival of nonWilms tumor patients was similar to that of an age-matched control group. In 30 patients 24-hour creatinine clearance and 24-hour urinary protein excretion were measured. Proteinuria (greater than 150 mg./24 hours) was found in 8 of the 30 patients (27%) (p <0.001), renal insufficiency developed in 9 (30%) (p <0.0001) and hypertension occurred in 10% (p >0.10). Children with an acquired solitary kidney are at increased risk for proteinuria and renal insufficiency.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalJournal of Urology
Issue number2 II
StatePublished - 1992


  • kidney failure
  • nephrectomy
  • proteinuria

ASJC Scopus subject areas

  • Urology


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