Profiling of lymphoma from formalin-fixed paraffin-embedded tissue

Ryan S. Robetorye, Alanna Maguire, Alison C. Rosenthal, Lisa M. Rimsza

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Molecular profiling of lymphoma samples has contributed enormously to our understanding of disease biology leading to detailed descriptions of diagnostic categories. These studies have also helped the field to recognize different subtypes of disease, different diseases that share similar cellular pathway perturbations, different immune responses, and different prognostic groups. While nearly all of these discoveries were made using unfixed, snap-frozen materials, with few exceptions, clinical biopsy materials are comprised of formalin-fixed and paraffin-embedded (FFPE) tissues. Here, we describe the impact of molecular profiling on the field of lymphoma, the challenges associated with using FFPE tissues for downstream molecular diagnostic testing, the various molecular profiling techniques, and also provide an example of the clinical application of a molecular profiling test of lymphoma using FFPE tissues.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalSeminars in Hematology
Issue number1
StatePublished - Jan 2019

ASJC Scopus subject areas

  • Hematology


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