Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs

J. William Schleifer, Komandoor Srivathsan

Research output: Chapter in Book/Report/Conference proceedingChapter


Many drugs, including both antiarrhythmic and non-antiarrhythmic medications, affect the ion channels and receptors of the heart with the potential to produce a proarrhythmic action. The proarrhythmic action of these drugs is influenced by electrolyte disturbances, hemodynamic abnormalities, and conditions affecting the metabolism and excretion of the medication. This chapter will discuss the mechanisms of proarrhythmic states commonly encountered, illustrate characteristic scenarios, and explain treatment strategies for medication-induced proarrhythmic states. As it is often difficult clinically to differentiate between arrhythmias occurring at therapeutic medication concentrations and those occurring at toxic levels, the treatment of antiarrhythmic toxicity is also discussed.

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Number of pages24
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
StatePublished - Jan 1 2015


  • Antiarrhythmic
  • Automaticit
  • Digoxin
  • Potassium channel
  • Sodium channel

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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