Principles of Good Clinical Trial Design

Ming Wen An; Quyen Duong; Jennifer Le-Rademacher; Sumithra J. Mandrekar

doi:10.1016/j.jtho.2020.05.005

Principles of Good Clinical Trial Design

Ming Wen An, Quyen Duong, Jennifer Le-Rademacher, Sumithra J. Mandrekar

Quantitative Health Sciences

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Abstract

Clinical trials are a fundamental component of medical research and serve as the main route to obtain evidence of the safety and efficacy of treatment before its approval. A trial's ability to provide the intended evidence hinges on appropriate design, background knowledge, trial rationale to sample size, and interim monitoring rules. In this article, we present some general design principles for investigators and their research teams to consider when planning to conduct a trial.

Original language	English (US)
Pages (from-to)	1277-1280
Number of pages	4
Journal	Journal of Thoracic Oncology
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/j.jtho.2020.05.005
State	Published - Aug 2020

Keywords

Clinical trial
Collaboration
Design
Principles

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine

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10.1016/j.jtho.2020.05.005

Cite this

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Principles of Good Clinical Trial Design

Abstract

Keywords

ASJC Scopus subject areas

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