TY - JOUR
T1 - Principles of applied neurogastroenterology
T2 - Physiology/motility- sensation
AU - Kellow, John E.
AU - Delvaux, M.
AU - Azpiroz, F.
AU - Camilleri, M.
AU - Quigley, E. M.M.
AU - Thompson, D. G.
PY - 1999
Y1 - 1999
N2 - Many of the symptoms characteristic of the functional gastrointestinal disorders (FGID) are consistent with dysfunction of the motor and/or sensory apparatus of the digestive tract. Those aspects of sensorimotor dysfunction most relevant to the FGID include alterations in: gut contractile activity; myoelectrical activity; tone and compliance; and transit, as well as an enhanced sensitivity to distension, in each region of the gastrointestinal tract. Assessment of these phenomena involves a number of techniques, some well established and others requiring further validation. Using such techniques, researchers have reported a wide range of alterations in sensory and in motor function in the FGID. Importantly, however, relationships between such dysfunction and symptoms have been relatively weak, and so the clinical relevance of the former remains unclear. Moreover, the proportions of patients in the various symptom subgroups who display dysfunction, and the extent and severity of their symptoms, require better characterization. On a positive note, progress is occurring on several fronts, especially in relation to functional dyspepsia and irritable bowel syndrome, and based on the data gathered to date, a number of areas where further advances are required can be highlighted.
AB - Many of the symptoms characteristic of the functional gastrointestinal disorders (FGID) are consistent with dysfunction of the motor and/or sensory apparatus of the digestive tract. Those aspects of sensorimotor dysfunction most relevant to the FGID include alterations in: gut contractile activity; myoelectrical activity; tone and compliance; and transit, as well as an enhanced sensitivity to distension, in each region of the gastrointestinal tract. Assessment of these phenomena involves a number of techniques, some well established and others requiring further validation. Using such techniques, researchers have reported a wide range of alterations in sensory and in motor function in the FGID. Importantly, however, relationships between such dysfunction and symptoms have been relatively weak, and so the clinical relevance of the former remains unclear. Moreover, the proportions of patients in the various symptom subgroups who display dysfunction, and the extent and severity of their symptoms, require better characterization. On a positive note, progress is occurring on several fronts, especially in relation to functional dyspepsia and irritable bowel syndrome, and based on the data gathered to date, a number of areas where further advances are required can be highlighted.
KW - Functional dyspepsia
KW - Functional gut disorders
KW - Gastrointestinal tract
KW - Irritable bowel syndrome
KW - Motility
KW - Rome II
KW - Sensation
KW - Visceral hyperalgesia
UR - http://www.scopus.com/inward/record.url?scp=0032883940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032883940&partnerID=8YFLogxK
U2 - 10.1136/gut.45.2008.ii17
DO - 10.1136/gut.45.2008.ii17
M3 - Review article
C2 - 10457040
AN - SCOPUS:0032883940
SN - 0017-5749
VL - 45
SP - II17-II24
JO - Gut
JF - Gut
IS - SUPPL. 2
ER -