Primary pancreatic cystic neoplasms of the pancreas revisited. Part IV: Rare cystic neoplasms

George H. Sakorafas, Vasileios Smyrniotis, Kaye M. Reid-Lombardo, Michael G. Sarr

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Primary pancreatic cystic neoplasms are being recognized with increasing frequency due to modern imaging techniques. In addition to the more common cystic neoplasms - serous cystadenoma, primary mucinous cystic neoplasm, and intraductal papillary mucinous neoplasm - there are many other less common neoplasms that appear as cystic lesions. These cystic neoplasms include solid pseudopapillary neoplasm of the pancreas (the most common rare cystic neoplasm), cystic neuroendocrine neoplasm, cystic degeneration of otherwise solid neoplasms, and then the exceedingly rare cystic acinar cell neoplasm, intraductal tubular neoplasm, angiomatous neoplasm, lymphoepithelial cysts (not true neoplasms), and few others of mesenchymal origin. While quite rare, the pancreatic surgeon should at the least consider these unusual neoplasms in the differential diagnosis of potentially benign or malignant cystic lesions of the pancreas. Moreover, each of these unusual neoplasms has their own natural history/tumor biology and may require a different level of operative aggressiveness to obtain the optimal outcome.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalSurgical Oncology
Issue number3
StatePublished - Sep 1 2012


  • Acinar cell neoplasm
  • Choriocarcinoma
  • Cystic lymphangioma
  • Cystic neoplasms of pancreas
  • Hemangioma
  • Intraductal tubular neoplasm
  • Neuroendocrine neoplasm
  • Pseudopapillary neoplasm of the pancreas
  • Teratoma

ASJC Scopus subject areas

  • Surgery
  • Oncology


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