Primary ovarian malignant lymphoma presenting as ovarian carcinomatosis: A case report and literature review

U. V. Kapetanakis, N. J. Karlin, A. E. McCullough, P. M. Magtibay

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1 Scopus citations


Primary ovarian lymphoma may present with a clinical scenario consistent with advanced epithelial ovarian carcinoma. Although ovarian lymphoma is a rare entity, accounting for 0.5% of all non-Hodgkin's lymphoma and 1.5% of all ovarian neoplasms, it should be included in the differential diagnosis of an ovarian mass. Case: We report a case of a 78-year-old woman who presented with an ovarian neoplasm suggestive of advanced ovarian carcinoma. During diagnostic laparoscopy, biopsies were obtained with frozen section analysis revealing malignant lymphoma. Further histopathologic analysis revealed a diffuse large B-cell lymphoma (DLBCL). The treatment plan was for six cycles of R-CHOP chemotherapy. A drammatic response was noted after only three cycles of R-CHOP. Conclusion: Primary ovarian lymphoma presenting as an ovarian tumor is exceedingly rare. Since the prognosis and treatment of lymphoma differs significantly from ovarian carcinoma, a representative tissue sample of the adnexal tumor should be obtained and sent for frozen section analysis to establish the diagnosis. Principal treatment for non-Hodgkin's lymphoma is chemotherapy without surgical cytoreductive efforts.

Original languageEnglish (US)
Pages (from-to)701-702
Number of pages2
JournalEuropean Journal of Gynaecological Oncology
Issue number6
StatePublished - 2010


  • Chemotherapy
  • Cytoreduction
  • Non-Hodgkin's lymphoma
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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