Primary Malignant Melanoma of the Sinonasal Cavity: MR Imaging Evaluation

David M. Yousem, Cheng Li, Kathleen T. Montone, Linda Montgomery, Laurie A. Loevner, Vijay Rao, Tae Sub Chung, Yasuyuki Kimura, Richard E. Hayden, Gregory S. Weinstein

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


To evaluate the magnetic resonance (MR) imaging characteristics of primary malignant melanoma of the sinonasal cavity, T1- and T2-weighted MR images of 12 patients with primary sinonasal melanoma were retrospectively reviewed. Gadolinium-enhanced imaging was performed in seven cases. The MR images were compared with histopathologic results. There were seven melanotic melanomas and five amelanotic melanomas; hemorrhage was present in three melanotic and two amelanotic melanomas. The seven melanotic melanomas were hyperintense to gray matter on T1-weighted images (whether hemorrhage was present or not), consistent with the paramagnetic effect of melanin. Four of the five amelanotic melanomas had intermediate signal intensity on T1-weighted images; one was not detected. On T2-weighted images, all of the melanomas detected had intermediate though variable signal intensity compared with that of gray matter. On gadolinium-enhanced images, all cases demonstrated mild to moderate enhancement. The signal intensity of sinonasal melanoma appears to vary according to the histopathologic components of the tumor. High signal intensity within the lesion on T1-weighted images suggests the presence of melanin.

Original languageEnglish (US)
Pages (from-to)1101-1110
Number of pages10
Issue number5
StatePublished - 1996


  • Gadolinium, 23.12143, 261.12143
  • Melanoma, 23.371, 261.371
  • Nose, neoplasms, 261.371 paranasal sinuses, neoplasms, 23.371

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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