Primary lateral sclerosis: A neuropsychological study

Richard J. Caselli, Benn E. Smith, David Osborne

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Nine patients with clinically diagnosed, radiologically supported primary lateral sclerosis underwent cognitive testing. None was demented, but eight had mild cognitive impairment. Performances were most consistently impaired on neuropsychological tests sensitive to frontal lobe functions, followed by tests sensitive to memory. Cognitive testing may be useful in helping to establish a cortical localization in patients with the syndrome of progressive spasticity. There are potential nosologic relations between primary lateral sclerosis and other degenerative frontal lobe syndromes, such as frontal lobe dementia and progressive spasticity with dementia.

Original languageEnglish (US)
Pages (from-to)2005-2009
Number of pages5
Issue number11
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Clinical Neurology


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