Primary Lateral Sclerosis

Yvonne D. Rollins, Björn Oskarsson, Steven P. Ringel

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationInternational Neurology
Subtitle of host publicationA Clinical Approach
Number of pages2
ISBN (Print)9781405157384
StatePublished - May 18 2010


  • Clinical syndrome of PLS - rare, accounting for 1-3% of patients with motor neuron disease
  • EMG, useful in distinguishing PLS from ALS - based on absence of diffuse chronic denervation
  • Etiology of motor neuron degeneration - remaining unknown
  • No curative treatment - available for PLS
  • PLS, a diagnosis of exclusion - other disorders, including ALS
  • Primary lateral sclerosis
  • Primary lateral sclerosis (PLS), primary upper motor neuron (UMN) disorder
  • Progressive lower extremity spasticity without significant loss of strength - classic initial symptom

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine

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