Abstract
Rituximab (RTX) improves the outcome in patients with systemic diffuse large B-cell lymphoma (DLBCL), but its benefit in primary central nervous system lymphoma (PCNSL) is unclear. In the present study, a single-institution retrospective analysis was performed for 12 patients with newly diagnosed PCNSL treated with combined high-dose methotrexate (HD-MTX) and RTX. MTX was administered biweekly at 8 g/m2/dose until a complete response (CR) was achieved or for a maximum of eight doses. RTX was provided for a total of eight weekly doses at 375 mg/m2/dose. Following a median of 11 cycles of MTX, the radiographic overall response rate was 91% and the CR rate was 58%. A CR was achieved after a median 6 cycles of MTX. The median progression-free survival time was 22 months and the median overall survival time has not yet been attained. These results compare favorably to single-agent HD-MTX and suggest a role for immunochemotherapy in the treatment of PCNSL.
Original language | English (US) |
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Pages (from-to) | 3471-3476 |
Number of pages | 6 |
Journal | Oncology Letters |
Volume | 11 |
Issue number | 5 |
DOIs | |
State | Published - May 2016 |
Keywords
- High-dose methotrexate
- Non-Hodgkin's lymphoma
- Primary central nervous system lymphoma
- Rituximab
ASJC Scopus subject areas
- Oncology
- Cancer Research