Primary amyloidosis presenting as upper limb multiple mononeuropathies

Jennifer A. Tracy, Peter J. Dyck, P. James B. Dyck

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Peripheral neuropathy in primary (AL) amyloidosis is usually lower-limb predominant, length-dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. We report a patient with stepwise progressive, multiple upper limb mononeuropathies that were due to nerve biopsy-proven primary amyloidosis (lambda light chain), with no systemic or autonomic features. Recognition that light chain amyloidosis may be the cause of a multiple mononeuropathy pattern adds to the differential diagnosis of this clinical phenotype.

Original languageEnglish (US)
Pages (from-to)710-715
Number of pages6
JournalMuscle and Nerve
Issue number5
StatePublished - May 2010


  • Amyloid neuropathy
  • Amyloidosis
  • Mononeuritis multiplex
  • Necrotizing vasculitis
  • Nerve biopsy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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