Prevention of wound contamination using DuraPrep™ solution plus Ioban™ 2 drapes

Cassie Jacobson, Douglas R. Osmon, Arlen Hanssen, Robert T. Trousdale, Mark W. Pagnano, Janine Pyrek, Elie Berbari, James Naessens

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The use of the preoperative skin preparation DuraPrep™ is thought to enhance the adhesion qualities of an incise drape. If there is less drape lift it was hypothesized that there may be a reduction in wound contamination. We did a single-center, randomized trial to determine if a preoperative skin preparation containing DuraPrep™ solution plus Ioban™ 2 drapes reduced wound contamination in total joint replacement surgery compared with a povidone iodine scrub and paint plus Ioban 2 drapes. Secondary research questions focused on comparisons of differences in drape lift and cost between the two groups. Of the 176 evaluable patients, the proportion of patients with a contaminated wound was similar in the two groups (DuraPrep 28.0% versus povidone iodine 36.4%). The mean drape lift in the DuraPrep group was less than the povidone iodine group (1.5 cm2 versus 9.9 cm2 respectively). The mean cost of prepping was lower for the DuraPrep group compared with the povidone iodine group ($93.36 and $248.91, respectively). A preoperative skin preparation regimen containing DuraPrep solution plus Ioban 2 drapes is equivalent to a povidone iodine scrub and paint and Ioban 2 for the prevention of wound contamination during total joint replacement surgery. Improved drape lift and cost may influence the choice between the two methods. Level of Evidence: Therapeutic diagnostic study, Level 1 (randomized, prospective study).

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalClinical orthopaedics and related research
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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