Prevention of hepatocellular carcinoma: Progress and challenges

A. M. Shire, L. R. Roberts

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Hepatocellular carcinoma (HCC) is a lethal cancer for both men and women and is caused by multiple risk factors. Most patients with HCC have an underlying liver disease caused by either chronic viral infection due to hepatitis B or hepatitis C virus or non-viral etiologic risk factors such as alcohol, fatty liver disease, dietary aflatoxin exposure, smoking and diabetes mellitus. While these risk factors are progressively and persistently damaging the liver, the majority of patients show very few symptoms of HCC. By the time symptoms appear the cancer is typically at a very advanced stage with limited options for treatment. In order to prevent death from HCC, it is therefore critically important to reduce the prevalence of the major risk factors, identify and treat those at high risk for development of HCC, and institute effective surveillance strategies for early diagnosis and treatment of HCC. This article reviews the recent progress and current challenges to the prevention of HCC.

Original languageEnglish (US)
Pages (from-to)49-64
Number of pages16
JournalMinerva Gastroenterologica e Dietologica
Issue number1
StatePublished - Mar 1 2012


  • Carcinoma, hepatocellular
  • Hepatitis B
  • Hepatitis C
  • Virus diseases

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Gastroenterology


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