Prevalence of metabolic syndrome in patients with pulmonary hypertension

Kamonpun Ussavarungsi, Colleen S. Thomas, Charles D. Burger

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background and Aims: To determine the prevalence of metabolic syndrome (MetS) – a potential phenotypical risk for pulmonary hypertension (PH) – in patients with PH and by PH diagnostic group including group 1 pulmonary arterial hypertension (PAH); group 1.1 idiopathic PAH, groups 1.2 heritable PAH, 1.3 drug and toxin induced, 1.4 associated PAH, group 2 PH with left heart disease, group 3 PH associated with lung disease and/or hypoxemia, group 4 PH owing to chronic thrombotic and/or embolic disease, and group 5 PH from multifactorial mechanisms. Methods: We conducted a retrospective chart review of patients referred to Mayo Clinic in Florida from January 1990 to October 2013 (N = 1287). Only patients whom PH was confirmed by right heart catheterization were included (N = 640). MetS was defined with at least three of the following: systemic hypertension, diabetes mellitus, hyperlipidemia and body mass index > 30. Results: MetS was prevalent in 247 of 640 (39%) with PH: 13% in group 1.1 PAH, 12% in groups 1.2–1.4 PAH, 54% in group 2, 55% in group 3, 23% in group 4 and 24% in group 5. After adjusting for age, sex and race, diagnostic subgroup analysis revealed a higher prevalence of MetS in WHO Group 2 PH patients [adjusted odd ratios (OR): 2.58, P < 0.0001] and WHO group 3 PH (adjusted OR: 2.77, P < 0.0001) when compared to group 1 PH. Conclusion: The prevalence of MetS was observed in 39% of patients with PH; however, among PH patients, the prevalence was higher in group 2 and 3 PH.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalClinical Respiratory Journal
Issue number6
StatePublished - Nov 2017


  • metabolic syndrome – obesity – prevalence – pulmonary hypertension – pulmonary venous hypertension

ASJC Scopus subject areas

  • Genetics(clinical)
  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy


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