Pretibial myxedema (thyroid dermopathy)

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Editorial Perspective: Pretibial myxedema (thyroid dermopathy) is the sine qua non of the dermatologic manifestations of thyroid disease. Although any medical student can reflexively state that pretibial myxedema is a hallmark of Graves disease, how many clinicians realize that the term is a misnomer? That thyroid dermopathy is not necessarily limited to the pretibial region and is not exclusively seen in patients with Graves disease are just two facts frequently misconceived about this condition. The reality is that much has been learned about the immunologic pathogenesis of thyroid der-mopathy, a condition that results from the accumulation of the glycosaminoglycans, hyaluronic acid, and chondroitin sulfate in the dermis. A precise understanding of its pathogenesis, however, remains to be determined. This chapter surveys the clinical, biological, and therapeutic landscape of thyroid dermopathy. By understanding its natural history, eliminating or reducing predisposing factors such as smoking and obesity, appreciating the complexities of the immunologic aberrations leading to mucin deposition, and having a logical approach to therapy, clinicians should be able to at least ameliorate this chronic, occasionally severe, recalcitrant disorder.

Original languageEnglish (US)
Title of host publicationThyroid Disorders with Cutaneous Manifestations
PublisherSpringer Berlin Heidelberg
Number of pages17
ISBN (Print)9781848001862
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)


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