Pressor response to 5-hydroxytryptamine in pithed guinea pigs

M. K. Krstic, Z. S. Katusic

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1 Scopus citations


In pithed guinea pigs, general characteristics and the origin of the pressor response to intravenous administration of 5-HT were analysed. The pressor effect of 5-HT (12-200 μg/kg) was prominent and dose-dependent. In animals pretreated with nicotine, reserpine, bretylium or 6-hydroxydopamine the pressor response was markedly diminished. The reduction of the pressor effect produced with bretylium or 6-hydroxydopamine was significantly smaller than that produced with reserpine. It is concluded that, in guinea pigs, unlike in rats, cats and dogs, the pressor response to 6-HT is in part due to the activation of both sympathetic ganglia and the adrenals followed by the release of catecholamines from sympathetic nerve terminals and the adrenal medulla.

Original languageEnglish (US)
Pages (from-to)530-531
Number of pages2
JournalIRCS Medical Science
Issue number6
StatePublished - 1981

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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