Preparing the United States for high-sensitivity cardiac troponin assays

Frederick K. Korley, Allan S. Jaffe

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


It is only a matter of time before the use of high-sensitivity cardiac troponin assays (hs-cTn) becomes common throughout the United States. In preparation for this inevitability, this article raises a number of important issues regarding these assays that deserve consideration. These include: the need for the adoption of a universal nomenclature; the importance of defining uniform criteria for reference populations; the challenge of discriminating between acute and nonacute causes of hs-cTn elevations, and between type 1 and type 2 acute myocardial infarction (AMI); factors influencing the analytical precision of hs-cTn; ascertaining the optimal duration of the rule-out period for AMI; the need for further evaluation to determine the causes of a positive hs-cTn in non-AMI patients; and the use of hs-cTn to risk-stratify patients with disease conditions other than AMI. This review elaborates on these critical issues as a means of educating clinicians and researchers about them.

Original languageEnglish (US)
Pages (from-to)1753-1758
Number of pages6
JournalJournal of the American College of Cardiology
Issue number17
StatePublished - Apr 30 2013


  • high-sensitivity troponin
  • ischemia
  • myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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