Premorbid personality characteristics in Alzheimer's disease: An exploratory case-control study

M. Malinchoc, W. A. Rocca, R. C. Colligan, K. P. Offord, E. Kokmen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Linking data from a case-control study of Alzheimer's disease (AD) with data from a Minnesota Multiphasic Personality inventory (MMPI) outpatient study, we identified 13 AD cases and 16 controls for case-control comparison. The mean time between personality testing and onset of AD (or corresponding age for controls) was 13 years in cases and 14 years in controls. AD cases, but not the controls, had scores significantly greater than the normative reference on MMPI scales measuring social introversion (p = 0.05) and pessimism (p = 0.01). When compared to controls, AD cases had significantly greater scores on the social introversion scale (p = 0.03). Despite the small sample size and some design limitations of this exploratory study, our findings may suggest that subjects who score higher on these personality scales have a greater risk for AD.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalEuropean Journal of Neurology
Issue number3
StatePublished - 1997


  • Alzheimer's disease
  • Case-control study
  • Minnesota Multiphasic Personality Inventory (MMPI)
  • Pessimism
  • Premorbid personality
  • Social introversion

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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