TY - JOUR
T1 - Pregnancy-associated plasma protein-A expression in human breast cancer
AU - Mansfield, Aaron S.
AU - Visscher, Daniel W.
AU - Hart, Steven N.
AU - Wang, Chen
AU - Goetz, Matthew P.
AU - Oxvig, Claus
AU - Conover, Cheryl A.
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.
AB - Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.
KW - Breast cancer
KW - Immunohistochemistry
KW - Pregnancy-associated plasma protein-A
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U2 - 10.1016/j.ghir.2014.10.007
DO - 10.1016/j.ghir.2014.10.007
M3 - Article
C2 - 25468445
AN - SCOPUS:84919474294
SN - 1096-6374
VL - 24
SP - 264
EP - 267
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
IS - 6
ER -