Abstract
THE cloning and pharmacological characterization of mouse 5-HT(1D) receptors as well as the comparative analysis of its embryonic expression vs that of 5-HT(1B) receptors are reported. High densities of both 5-HT(1D) receptors mRNA and specific 5-HT(1D) binding sites were detected at 8, 9.5, 10.5 and 13.5 days of prenatal development. In contrast, no specific 5- HT(1B) binding sites could be detected until 13.5 days of development, when they were present at lower levels than 5-HT(1D) receptors. This differs markedly from the situation in the adult brain, in which 5-HT(1B) receptors are present at a much higher density than the 5-H(1D) subtype. These data suggest the involvement of 5-HT(1D) receptors in the mitogenic and proliferative effects of serotonin during early embryonic development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3655-3660 |
| Number of pages | 6 |
| Journal | NeuroReport |
| Volume | 8 |
| Issue number | 17 |
| DOIs | |
| State | Published - Jan 1 1997 |
Keywords
- 5-HT(1B) receptors
- 5-HT(1D) receptors
- CNS
- Development
- Embryogenesis
- Mouse
- Serotonin
ASJC Scopus subject areas
- Neuroscience(all)