Prediction of Atrial Fibrillation Using Machine Learning: A Review

Andrew S. Tseng, Peter A. Noseworthy

Research output: Contribution to journalReview articlepeer-review


There has been recent immense interest in the use of machine learning techniques in the prediction and screening of atrial fibrillation, a common rhythm disorder present with significant clinical implications primarily related to the risk of ischemic cerebrovascular events and heart failure. Prior to the advent of the application of artificial intelligence in clinical medicine, previous studies have enumerated multiple clinical risk factors that can predict the development of atrial fibrillation. These clinical parameters include previous diagnoses, laboratory data (e.g., cardiac and inflammatory biomarkers, etc.), imaging data (e.g., cardiac computed tomography, cardiac magnetic resonance imaging, echocardiography, etc.), and electrophysiological data. These data are readily available in the electronic health record and can be automatically queried by artificial intelligence algorithms. With the modern computational capabilities afforded by technological advancements in computing and artificial intelligence, we present the current state of machine learning methodologies in the prediction and screening of atrial fibrillation as well as the implications and future direction of this rapidly evolving field.

Original languageEnglish (US)
Article number752317
JournalFrontiers in Physiology
StatePublished - Oct 28 2021


  • atrial fibrillation
  • deep learning
  • echocardiography
  • electrocardiogram
  • machine learning
  • prediction
  • risk factor

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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